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Published on: April 7, 2015
A classic and fatal case of Streptococcus mutans subacute bacterial endocarditis; A now potentially underappreciated
1University of Maryland Medical Center, Department of Medicine, Division of Infectious Disease. 22 South Greene St, Baltimore MD 21201, United States.
Abstract:
Acute bacterial endocarditis is now common and easily suspected and recognized in the setting of prosthetic valves, injection drug use, or bacteremia with virulent organisms. Conversely, subacute bacterial endocarditis has drastically decreased in incidence, and recognition may be further hampered by the indolent non-specific presentation. Delayed diagnosis is common and can lead to serious complications and fatalities. We describe a patient found to have Streptococcus mutans subacute bacterial endocarditis, who presented with classic risk factors and findings, and who died shortly after presentation due to hemorrhagic conversion of an embolic stroke in the setting of anticoagulation. It is critical that all cases of streptococcal bacteremia be appropriately evaluated and treated, and that Streptococcus spp. not ever be routinely considered a blood culture 'contaminant'.
Insights
Subacute bacterial endocarditis, though rare, presents subtly and can be fatal. Prompt evaluation of streptococcal bacteremia is crucial to prevent severe complications like stroke.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Subacute bacterial endocarditis (SBE) incidence has declined, often presenting with non-specific symptoms, complicating early diagnosis.
- Acute bacterial endocarditis is more common and readily identified, particularly in patients with prosthetic valves, intravenous drug use, or known bacteremia.
Observation:
- A case of Streptococcus mutans subacute bacterial endocarditis is presented.
- The patient exhibited typical risk factors and clinical signs associated with SBE.
- Despite classic presentation, diagnosis was delayed, leading to fatal outcomes.
Findings:
- The patient experienced hemorrhagic conversion of an embolic stroke while on anticoagulation therapy.
- Streptococcus mutans was identified as the causative agent of the subacute bacterial endocarditis.
- Delayed recognition and treatment contributed to the adverse outcome.
Implications:
- All instances of streptococcal bacteremia require thorough evaluation and appropriate treatment.
- Streptococcus species should not be dismissed as mere blood culture contaminants.
- Increased awareness and timely intervention are vital for managing subacute bacterial endocarditis to prevent mortality and morbidity.
Related Concept Videos
Endocarditis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Rheumatic Heart Disease I: Introduction
Endocarditis III: Medical Management
Mitral Stenosis I: Introduction
Endocarditis IV: Nursing Management

