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Updated: Dec 29, 2025

Long-term In Vivo Tracking of Inflammatory Cell Dynamics Within Drosophila Pupae
Published on: June 14, 2018
Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
Anne-Claire Jacomin1, Ioannis P Nezis1
1School of Life Sciences, University of Warwick, Coventry, UK.
Abstract:
Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (CG16910) with the autophagic machinery is required for the degradation of the I-kappa B kinase complex. This regulatory mechanism is essential for the downregulation of the immune deficiency (IMD) pathway in response to commensal microbiota to prevent inflammation.
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