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Related Experiment Video

Updated: Dec 29, 2025

Roux-en-Y Gastric Bypass Operation in Rats
07:37

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Health benefits and risks during 10 years after Roux-en-Y gastric bypass.

M Chahal-Kummen1,2, O B K Salte3, S Hewitt4,5

  • 1Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Nydalen, PO Box 4950, 0424, Oslo, Norway. monica.chahal.kummen@gmail.com.

Surgical Endoscopy
|January 30, 2020
PubMed
Summary

Long-term Roux-en-Y gastric bypass (RYGB) leads to significant weight loss and comorbidity remission. However, substantial weight regain and common gastrointestinal symptoms negatively impact quality of life 10 years post-surgery.

Keywords:
Cardiovascular risk factorsGastric bypassGastrointestinal symptomsLong-term outcomesWeight loss

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Area of Science:

  • Bariatric surgery outcomes
  • Long-term metabolic and surgical effects
  • Gastrointestinal health and quality of life

Background:

  • Long-term (10-year) data on Roux-en-Y gastric bypass (RYGB) outcomes are scarce.
  • Understanding sustained weight loss and cardiovascular risk factor changes after RYGB is crucial.
  • Evaluating gastrointestinal symptoms and quality of life (QoL) post-RYGB is essential for comprehensive patient assessment.

Purpose of the Study:

  • To prospectively evaluate weight changes and cardiovascular risk factors 10 years after laparoscopic RYGB.
  • To assess gastrointestinal symptoms and QoL in patients at the 10-year follow-up mark.
  • To identify long-term complications and their impact on patient well-being.

Main Methods:

  • Prospective longitudinal cohort study design.
  • Inclusion of patients who underwent laparoscopic RYGB between May 2004 and November 2006.
  • Utilized Gastrointestinal Symptom Rating Scale (GSRS) and QoL questionnaires for 10-year follow-up.

Main Results:

  • Achieved 53.0% excess weight loss and 24.1% total weight loss at 10 years, with 53.2% achieving >50% EWL.
  • Observed significant weight regain (≥15%) in 63.3% of patients between years 2 and 10.
  • Reported remission rates of 56.8% for type 2 diabetes, 46.0% for dyslipidemia, and 41.4% for hypertension; common complications included internal hernia and gallstone disease.

Conclusions:

  • Laparoscopic RYGB demonstrates significant long-term weight loss and comorbidity remission up to 10 years.
  • A substantial proportion of patients experience significant weight regain, necessitating ongoing monitoring.
  • Prevalent gastrointestinal symptoms at 10 years negatively affect patient quality of life.