Related Experiment Video
Updated: Dec 29, 2025
04:04
Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
Published on: August 15, 2025
312
Tumorous formation of the forehead
Ivanka Temelkova1, Georgi Tchernev2
1Onkoderma - Clinic for Dermatology, Venereology and Dermatologic Surgery, General Skobelev 26, 1606, Sofia, Bulgaria. vanq2991@gmail.com.
Wiener Medizinische Wochenschrift (1946)
|January 30, 2020
Summary
A rare case of T-cell non-Hodgkin
Area of Science:
- Oncology
- Hematology
- Dermatology
Background:
- T-cell non-Hodgkin's lymphoma (NHL) is a rare subtype of lymphoma.
- Cutaneous manifestations can be the initial presentation of NHL.
- Accurate diagnosis is crucial for effective treatment.
Observation:
- A 16-year-old girl presented with nodular, erosive forehead tumors and lymphadenopathy.
- Initial treatments for presumed infections were ineffective, and the condition progressed.
- Histopathological and immunohistochemical analysis confirmed peripheral T-cell non-Hodgkin's lymphoma (CD3+, CD4+, CD8-, CD20-, CD30-, CD43-, ALK1-).
Findings:
- The patient was diagnosed with stage 4E T-cell lymphoma involving lymph nodes above and below the diaphragm.
- Immunohistochemistry was crucial in differentiating from other conditions and confirming the T-cell origin.
- CHOEP chemotherapy was initiated, resulting in a positive clinical response after the first cycle.
Implications:
- This case underscores the importance of considering rare diagnoses like T-cell lymphoma in adolescents with persistent or progressing skin lesions.
- Accurate immunohistochemical profiling is vital for correct diagnosis and treatment planning in cutaneous lymphomas.
- Early initiation of appropriate chemotherapy, such as CHOEP, can lead to favorable outcomes even in advanced-stage disease.
Related Concept Videos
01:14Cranial Bones: Superior and Posterior View
4.7K
The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
4.7K
01:22Sutures of the Skull
9.8K
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
9.8K
01:27Cranial Bones: Lateral View
4.2K
The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
4.2K
01:08Overview of the Skull
7.2K
The cranium (skull) is the skeletal structure of the head that supports the face and protects the brain. It is subdivided into the facial bones and the brain case, or cranial vault. The facial bones underlie the facial structures, form the nasal cavity, enclose the eyeballs, and support the teeth of the upper and lower jaws.
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
7.2K
01:14Muscles for Facial Expressions
4.4K
The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
4.4K
01:29Bone Formation by Intramembranous Ossification
9.8K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
9.8K