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A Novel Method: Super-selective Adrenal Venous Sampling
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The haemostatic system in acromegaly: a single-centre case-control study.

E Campello1, M Marobin1, M Barbot2

  • 1Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, via Giustiniani 2, Padua, Italy.

Journal of Endocrinological Investigation
|January 30, 2020
PubMed
Summary

Acromegaly patients exhibit hypercoagulability due to elevated fibrinogen, factor VIII, and thrombin generation. This pro-thrombotic state is more pronounced in the chronic phase of the disease.

Keywords:
Endocrine disordersHypercoagulabilityInflammationMicrovesiclesThrombin generation

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Area of Science:

  • Endocrinology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Acromegaly, a disorder caused by excess growth hormone, is associated with increased cardiovascular mortality.
  • The role of hemostatic balance and hypercoagulability in acromegaly pathogenesis remains incompletely understood.

Purpose of the Study:

  • To globally assess the coagulation profile in acromegaly patients.
  • To investigate the presence of hypercoagulability using traditional and global coagulation assays.

Main Methods:

  • Enrolled consecutive acromegaly outpatients and matched healthy controls.
  • Measured thromboelastometry, impedance aggregometry, coagulation factors, thrombin generation, and microvesicles.

Main Results:

  • Acromegaly patients showed higher fibrinogen, factor VIII, endogenous thrombin potential (ETP), and thrombin peak compared to controls.
  • Increased endothelial-derived microvesicles were observed in acromegaly patients.
  • Untreated acromegaly patients had lower ETP than treated patients.

Conclusions:

  • Hypercoagulability in acromegaly is primarily driven by elevated fibrinogen, factor VIII, and thrombin generation.
  • The pro-thrombotic state in acromegaly appears linked to the chronic nature of the disease.