Related Experiment Video
Updated: Dec 29, 2025
04:38
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
10.7K
Hemoglobin, anemia, and poststroke cognitive impairment: A cohort study
Weilei He1, Yiting Ruan1, Chengxiang Yuan1
1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
International Journal of Geriatric Psychiatry
|January 30, 2020
Summary
Anemia increases the risk of poststroke cognitive impairment (PSCI) in acute ischemic stroke patients. Managing hemoglobin levels may help reduce cognitive decline after a stroke.
Area of Science:
- Neurology
- Hematology
- Internal Medicine
Background:
- Anemia is a known risk factor for cognitive impairment.
- The relationship between hemoglobin levels and cognitive function post-stroke requires further investigation.
Purpose of the Study:
- To examine the association between hemoglobin levels, anemia, and poststroke cognitive impairment (PSCI) in patients with acute ischemic stroke.
- To determine if hemoglobin levels impact cognitive outcomes following an acute ischemic stroke.
Main Methods:
- Prospective follow-up of 326 patients with acute ischemic stroke for 1 month.
- Assessment of PSCI using the Mini-Mental State Examination (MMSE).
- Multiple regression models were used to analyze the impact of hemoglobin and anemia on PSCI, controlling for confounders.
Main Results:
- 193 (59.2%) patients developed PSCI within 1 month.
- Anemia was independently associated with an increased risk of PSCI (OR = 3.637, P = .021) after adjusting for confounders.
- Higher hemoglobin levels showed a trend towards better cognitive function, but this was not statistically significant after adjustments.
Conclusions:
- Low hemoglobin levels are linked to a higher risk of developing PSCI.
- Interventions targeting hemoglobin levels in stroke patients warrant further study to potentially reduce PSCI incidence.
