Related Experiment Video

Updated: Dec 29, 2025

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
10:32

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Published on: March 23, 2014

15.5K

[Possibilities for optimizing the pathogenetic therapy of purulent meningitis in children]

A A Vilnits1, N V Skripchenko1, E Yu Gorelik2

  • 1Pediatric Research and Clinical Center for Infectious Diseases, St. Petersburg, Russia; Saint-Petersburg State Pediatric Medical University, St. Petersburg, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|January 30, 2020
PubMed

Insights

This study shows that combining Cytoflavin and Sulodexide effectively treats pediatric purulent meningitis. The treatment shortens symptoms and improves patient outcomes.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Pharmacology

Background:

  • Purulent meningitis in children poses significant risks.
  • Standard treatments may have limitations in fully mitigating complications.

Purpose of the Study:

  • To evaluate the efficacy of combined Cytoflavin and Sulodexide therapy in pediatric purulent meningitis.
  • To assess the impact on clinical course, symptom duration, and patient outcomes.

Main Methods:

  • A study involving 50 children (aged 5-17) diagnosed with purulent meningitis.
  • Treatment group received Cytoflavin and Sulodexide; comparison group received standard antibacterial therapy.
  • Key indicators monitored included fever duration, neurological symptoms, cerebrospinal fluid (CSF) recovery, and hematological parameters (leukocytes, D-dimer).

Main Results:

  • The combined therapy group demonstrated a reduced duration of cerebral and meningeal symptoms.
  • Normalization of hematological parameters, including leukocytes, desquamated epithelial cells (DEC), and D-dimer, was observed.
  • Improved outcomes were noted in the treatment group compared to standard care.

Conclusions:

  • Combined Cytoflavin and Sulodexide therapy is beneficial for managing purulent meningitis in children.
  • This combination therapy accelerates recovery and enhances overall patient outcomes.
  • Further research may explore long-term effects and optimal dosing strategies.
Abstract

Keywords:
CytoflavinSulodexidechildrenpurulent meningitistreatment

More Related Videos

Author Spotlight: Characterizing Airway Environments to Advance Model Systems and Antimicrobial Discovery in Cystic Fibrosis and Chronic Respiratory Infections06:19

Author Spotlight: Characterizing Airway Environments to Advance Model Systems and Antimicrobial Discovery in Cystic Fibrosis and Chronic Respiratory Infections

Published on: October 11, 2024

3.2K
Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

7.6K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
160
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
230
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
690
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
147
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
359
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
186