Related Experiment Video
Updated: Dec 29, 2025
Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
Published on: December 7, 2018
[Thrombodynamic correlates of catatonia severity in children with autism]
O S Brusov1, N V Simashkova1, N S Karpova1
1Mental Health Research Center, Moscow, Russia.
Insights
Children with autism spectrum disorder (ASD) and catatonia show hypercoagulation. Increased clot growth rates and reduced spontaneous clot formation time correlate with catatonia severity, suggesting hemostasis normalization is key for treatment.
Area of Science:
- Pediatric Neurology
- Hematology
- Psychiatry
Background:
- Infantile psychosis and catatonia are associated with autism spectrum disorder (ASD).
- Hypercoagulation, an abnormal increase in blood clotting, may play a role in ASD-related catatonia.
Purpose of the Study:
- To investigate the correlation between thrombodynamics parameters and catatonia severity in children with ASD.
- To assess hypercoagulation markers in children diagnosed with infantile psychosis within ASD.
Main Methods:
- Twenty-four children (ages 3-13) with ASD and catatonia were studied.
- Catatonia severity was assessed using the Bush-Francis Catatonia Rating Scale (BFCRS).
- Thrombodynamic tests were performed on platelet-free plasma to measure clot growth parameters.
Main Results:
- Thrombodynamic parameters indicated hypercoagulation, with significantly higher clot growth rates (V, Vi, Vst) and reduced time to spontaneous clot formation (Tsp).
- Catatonia severity positively correlated with initial clot growth rate (Vi) and negatively with Tsp.
- Longer Tsp, indicating decreased procoagulant activity, was associated with reduced catatonia severity.
Conclusions:
- The findings suggest a link between plasma and platelet hemostasis abnormalities and catatonia in children with ASD.
- Normalizing hemostasis may be a crucial therapeutic target for improving treatment outcomes in these patients.
Aim:
To study a correlation between the values of thrombodynamics parameters of hypercoagulation measured by the thrombodynamics test and the severity of catatonia in children with infantile psychosis in childhood autism (F84.02).
Material And Methods:
Twenty-four patients (22 boys and 2 girls) aged from 3 to 13 years, were studied. The severity of catatonia was determined by BFCRS. A thrombodynamic test was performed in platelet-free plasma using the analyzer T-2 Thrombodynamics Device (Hemacore LLC, Russia).
Results:
Thrombodynamic (TD) parameters of clot growth rates from the activator (V, Vi and Vst) were statistically significantly higher than normal values. Similar results were obtained for Clot Size at 30 min (CS, μm): Tlag and D values were within normal limits. The values of Time of appearance of spontaneous clots (Tsp min) were less than the lower limit values for the norm (30 min). Correlation analysis showed that the severity of catatonia is positively correlated with the initial clot growth rate (Vi) (p=0.009) and negatively with Tsp (p=0.002). With an increase in the time of appearance of spontaneous clots (due to a decrease in the procoagulant activity of platelet microparticles in the plasma of patients), the severity of catatonia in children with ASD decreases.
Conclusion:
The results suggest that normalizing plasma and platelet hemostasis is important for increasing the effectiveness of treatment of patients with ASD with catatonia.
Related Concept Videos
01:19Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
01:26Modeling in Therapy
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
01:28Conduct Disorder