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In vitro characterization of virulence factors among species of the Candida parapsilosis complex

Fábio Silvestre Ataides1, Carolina Rodrigues Costa1, Andressa Santana Santos1

  • 1Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, GO, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical
|January 30, 2020
PubMed
Abstract

Insights

Candida parapsilosis complex species exhibit varying virulence. This study analyzed enzyme activity, biofilm production, and cell adhesion in 87 strains, finding significant differences among isolates.

Area of Science:

  • Medical Mycology
  • Microbiology

Background:

  • Candida parapsilosis complex species display distinct prevalence and virulence.
  • Understanding these differences is crucial for clinical management.

Purpose of the Study:

  • To investigate variations in virulence factors among Candida parapsilosis complex strains.
  • To analyze hydrolytic enzyme activity, biofilm formation, and epithelial cell adhesion.

Main Methods:

  • Analysis of hydrolytic enzyme activity (proteinase, esterase, hemolysin).
  • Assessment of biofilm production.
  • Quantification of yeast adhesion to epithelial cells.
  • Study included 87 Candida parapsilosis complex isolates.

Main Results:

  • High prevalence of very strong proteinase (97.7%), esterase (63.2%), and hemolysin (82.8%) activity observed.
  • All isolates demonstrated biofilm production.
  • Average adherence to epithelial cells was 96.0 yeasts/100 cells.

Conclusions:

  • Candida parapsilosis complex isolates exhibit heterogeneous virulence factor expression.
  • Variability in enzyme activity, biofilm production, and adhesion potential exists within the complex.

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