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Updated: Dec 29, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Development of Minimal Diguanosinyl Motif toward RNA G-Quadruplex-Like Structures in Solution
Chandan Pal1, Tushar Kanti Chakraborty1
1Department of Organic Chemistry, Indian Institute of Science, Bengaluru, 560012, Karnataka, India.
Abstract:
Among the non-canonical structures of B-DNA, the G-quadruplex is of particular interest because of its well-defined conformation, high stability, and versatility. Herein we report our studies on the development of an amide-linked minimal diguanosinyl motif that forms a G-quadruplex-like structure in solution in the presence of potassium cations; various linear guanosine amino acid dimers were synthesized with linkers of different chain lengths to investigate the optimum flexibility required to form such structures.
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