Regenerative Endodontic Therapy with Platelet Rich Fibrin: Case Series

Area of Science:

• Dentistry
• Regenerative Medicine
• Endodontics

Background:

• Immature permanent teeth with pulp necrosis present a treatment challenge.
• Regenerative endodontic therapy (RET) offers a biological approach to restore tooth vitality.
• Platelet-rich fibrin (PRF) is a biomaterial investigated for its regenerative potential.

Observation:

• Three immature maxillary incisors with pulp necrosis and apical periodontitis underwent RET.
• Treatment involved irrigation with sodium hypochlorite, triple antibiotic paste (TAP) medication, and EDTA conditioning.
• Platelet-rich fibrin (PRF) served as a scaffold, with Mineral Trioxide Aggregate (MTA) and composite resin restoration.

Findings:

• At 36-month follow-up, no response to pulp sensibility tests was observed.
• Periapical radiographs and cone-beam computed tomography (CBCT) revealed decreased periapical lesions or evidence of healing in all treated teeth.
• Regenerative endodontic therapy (RET) with PRF demonstrated positive outcomes in healing periapical lesions.

Implications:

• RET with PRF may be a viable treatment option for immature necrotic teeth.
• Further research is warranted to optimize RET protocols and long-term efficacy.
• This approach holds potential for preserving immature permanent teeth and preventing extraction.