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Medication Options and Clinical Strategies for Treating Tardive Dyskinesia
1Department of Psychiatry & Behavioral Sciences, New York Medical College, Valhalla.
The Journal of Clinical Psychiatry
|January 30, 2020
Summary
Valbenazine and deutetrabenazine are FDA-approved treatments for tardive dyskinesia (TD). Understanding their differences and side effects helps clinicians personalize care and improve patient outcomes.
Area of Science:
- Neurology
- Pharmacology
Background:
- Tardive dyskinesia (TD) is a movement disorder often associated with antipsychotic medication use.
- Valbenazine and deutetrabenazine represent novel therapeutic options for TD management.
Purpose of the Study:
- To compare the efficacy and adverse effect profiles of valbenazine and deutetrabenazine.
- To guide clinicians in individualizing treatment strategies for tardive dyskinesia.
Main Methods:
- Review of FDA-approved medications for tardive dyskinesia.
- Analysis of clinical data on valbenazine and deutetrabenazine.
- Utilizing the Abnormal Involuntary Movement Scale (AIMS) for symptom assessment.
Main Results:
- Both valbenazine and deutetrabenazine are effective vesicular monoamine transporter type 2 (VMAT2) inhibitors for reducing TD symptoms.
- Key differences in adverse effects and clinical application exist between the two medications.
Conclusions:
- Personalized treatment approaches are crucial for optimizing TD management.
- Awareness of medication-specific profiles aids clinicians in selecting the most appropriate VMAT2 inhibitor.
- Effective treatment of TD can significantly alleviate patient burden.
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