Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

455
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
455
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

774
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
774
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

218
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
218
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

232
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
232
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

698
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
698
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

309
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
309

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autograft versus Allograft in Indirect Corneal Neurotization: A Systematic Review.

American journal of ophthalmology·2026
Same author

Proteomics-Based Soluble Urokinase Plasminogen Activator Receptor Levels Are Associated With Adverse Cardiovascular Outcomes in the General Population: Insights From the UK Biobank.

Journal of the American Heart Association·2026
Same author

uPAR/suPAR Signaling and Organ Crosstalk in Cardiovascular-Kidney-Metabolic Syndrome.

Circulation research·2026
Same author

Cardioprotective therapy in type 2 diabetes guided by a proteomic risk model: A randomized trial.

American journal of preventive cardiology·2026
Same author

Racism-Related Concern for Children and Central Hemodynamics in African American Women: A Longitudinal Study.

Biopsychosocial science and medicine·2026
Same author

Practical considerations in the management of patients with atrial fibrillation/flutter and hematologic malignancies.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026

Related Experiment Video

Updated: Dec 29, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.8K

Soluble Urokinase Receptor and Acute Kidney Injury.

Salim S Hayek1, David E Leaf1, Ayman Samman Tahhan1

  • 1From the Division of Cardiology, Department of Medicine, University of Michigan, Ann Arbor (S.S.H.); the Divisions of Renal Medicine (D.E.L., S. Sharma, S.S.W.) and Pulmonary and Critical Care Medicine (R.M.B.), Brigham and Women's Hospital, the Section of Nephrology, Department of Medicine, Boston University School of Medicine (S.S.W.), and the Divisions of Nephrology (S. Sever) and Cardiology (A.C., N.E.I., J.L.J.), Massachusetts General Hospital - all in Boston; Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta (A.S.T., M.R., A.A.Q.); the Department of Medicine, Rush University Medical Center, Chicago (X.W., R.R.D., M.M.A., C.W., J.R.); the Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston (D.S.-H., J.S.-C.P., M.W.H.); and the Veterans Affairs Pittsburgh Healthcare System and the University of Pittsburgh School of Medicine, Pittsburgh (S.D.W.).

The New England Journal of Medicine
|January 30, 2020
PubMed
Summary
This summary is machine-generated.

High levels of soluble urokinase plasminogen activator receptor (suPAR) are linked to acute kidney injury in patients undergoing procedures and in critical illness. Targeting suPAR may offer a new therapeutic strategy for preventing kidney damage.

More Related Videos

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.5K
Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

2.3K

Related Experiment Videos

Last Updated: Dec 29, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.8K
Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.5K
Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

2.3K

Area of Science:

  • Nephrology
  • Biochemistry
  • Immunology

Background:

  • Acute kidney injury (AKI) is a prevalent condition with significant morbidity and healthcare costs.
  • Soluble urokinase plasminogen activator receptor (suPAR), a signaling glycoprotein, is implicated in kidney disease pathogenesis.
  • The role of suPAR in predisposing individuals to AKI across diverse clinical settings requires further investigation.

Purpose of the Study:

  • To determine if elevated suPAR levels predict AKI in patients undergoing coronary angiography, cardiac surgery, and in critically ill individuals.
  • To elucidate the mechanisms underlying suPAR's role in AKI development using experimental models.
  • To evaluate suPAR as a potential therapeutic target for AKI.

Main Methods:

  • Plasma suPAR levels were measured pre-procedure in 3827 angiography patients and 250 cardiac surgery patients, and upon ICU admission for 692 critically ill patients.
  • AKI risk at 7 days and AKI or death at 90 days were assessed based on suPAR quartiles.
  • Experimental studies involved suPAR-overexpressing mice treated with contrast material and human kidney cells exposed to recombinant suPAR, with interventions using a uPAR monoclonal antibody.

Main Results:

  • Higher suPAR quartiles were significantly associated with increased odds of AKI (OR 2.66) and AKI or death at 90 days (OR 2.29) in angiography patients.
  • Similar associations were observed in cardiac surgery and critically ill cohorts.
  • Experimental models showed suPAR exacerbates AKI, increasing cellular energy demand and oxidative stress, which was attenuated by uPAR antibody treatment.

Conclusions:

  • Elevated suPAR levels are a significant risk factor for AKI in multiple clinical scenarios.
  • suPAR contributes to kidney injury through mechanisms involving cellular bioenergetics and oxidative stress.
  • Targeting the suPAR pathway presents a promising therapeutic avenue for AKI prevention and treatment.