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Related Experiment Videos

Widespread cutaneous herpes simplex type II infection.

F W Rosenberg, R K Schachter, K Givan

    Cutis
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    This case study details the first reported survival of an adult with widespread cutaneous herpes simplex type II infection. Treatment involved photodynamic inactivation therapy, showing potential for managing severe herpes simplex virus type II cases.

    Area of Science:

    • Virology
    • Dermatology
    • Infectious Diseases

    Background:

    • Herpes simplex virus type II (HSV-2) typically causes genital herpes but can lead to severe disseminated infections in immunocompromised individuals.
    • Widespread cutaneous HSV-2 infections are rare and associated with significant morbidity and mortality.
    • This study presents a unique case of disseminated cutaneous HSV-2 in an adult survivor.

    Observation:

    • A widespread cutaneous infection caused by herpes simplex virus type II was confirmed in an adult patient.
    • Viral presence was identified through characteristic cytopathic effects in Vero cell cultures.
    • Microscopic examination revealed enlarged, multinucleated syncytial cells and cell lysis, indicative of HSV-2 infection.

    Findings:

    • The patient survived a severe, culture-proven, disseminated cutaneous herpes simplex type II infection.

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  • Photodynamic inactivation therapy using acriflavine dye and fluorescent light was successfully employed.
  • This represents the first documented case of survival from such a widespread cutaneous HSV-2 infection.

    • Implications:

    • Photodynamic inactivation therapy shows promise as a treatment modality for severe, disseminated cutaneous herpes simplex virus type II infections.
    • Understanding the management of rare, severe HSV-2 presentations can inform clinical practice.
    • This case highlights the potential for recovery even in life-threatening viral skin infections.