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Spontaneous malignomas in Tupaia (tree shrew).

G Darai¹, L Zöller¹, W Hofmann²

¹Institut für Medizinische Virologie, University of Heidelberg.

American Journal of Primatology

|January 31, 2020

Summary

Spontaneous tumors were observed in captive tree shrews (Tupaia) over nine years. New Tupaia herpesviruses were isolated from tumor cells, marking the first report of such findings in this species.

Keywords:

Tupaia herpesvirus histopathology tumours

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Area of Science:

Comparative pathology
Virology
Oncology

Background:

Spontaneous tumors in exotic species require thorough investigation.
Tree shrews (Tupaia) are unique models for biomedical research.
Understanding tumor development in captive animals is crucial.

Purpose of the Study:

To document and characterize spontaneous malignomas in captive tree shrews.
To investigate potential viral etiologies associated with these tumors.
To establish a baseline for Tupaia oncology research.

Main Methods:

Long-term observation of a captive tree shrew colony over nine years.
Histopathological examination and classification of detected tumors.
Isolation and characterization of novel viruses from tumor tissues.

Main Results:

Nine cases of spontaneous malignomas were identified in imported tree shrews.
Histopathology confirmed the neoplastic nature of the observed growths.
Novel Tupaia herpesviruses were successfully isolated from two distinct tumor samples.

Conclusions:

This study presents the first report of spontaneous malignomas in captive tree shrews.
The isolation of Tupaia herpesviruses suggests a potential viral role in tumorigenesis.
Further research is warranted to explore the oncogenic potential of these newly identified viruses.