Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 29, 2025

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model
09:33

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model

Published on: February 28, 2014

49.5K

Primates: Their use in research on vasectomy.

Nancy J Alexander1

  • 1Department of Reproductive Physiology, Oregon Regional Primate Research Center, Beaverton, Oregon.

American Journal of Primatology
|January 31, 2020
PubMed
Summary

Vasectomy can lead to immune responses and inflammation in reproductive tissues in various species, including primates. Studies in monkeys suggest a potential link between vasectomy, immune complex formation, and increased arteriosclerosis, warranting further investigation in humans.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic Intermittent Ethanol and Withdrawal Suppress Evoked and Spontaneous GABA Release Onto Distinct Populations of Basolateral Amygdala Principal Neurons.

Addiction biology·2025
Same author

Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits.

bioRxiv : the preprint server for biology·2024
Same author

Chronic Ethanol Differentially Modulates Glutamate Release from Dorsal and Ventral Prefrontal Cortical Inputs onto Rat Basolateral Amygdala Principal Neurons.

eNeuro·2019
Same author

Requirement of Two Acyltransferases for 4- O-Acylation during Biosynthesis of Harzianum A, an Antifungal Trichothecene Produced by Trichoderma arundinaceum.

Journal of agricultural and food chemistry·2018
Same author

Role of Trichoderma arundinaceum tri10 in regulation of terpene biosynthetic genes and in control of metabolic flux.

Fungal genetics and biology : FG & B·2018
Same author

Chronic Social Isolation Stress during Peri-Adolescence Alters Presynaptic Dopamine Terminal Dynamics via Augmentation in Accumbal Dopamine Availability.

ACS chemical neuroscience·2018

Area of Science:

  • Reproductive immunology
  • Comparative pathology
  • Vascular biology

Background:

  • Vasectomy induces varied immune and pathological responses across species, including granuloma formation and orchitis.
  • Primates offer a valuable model for studying long-term vasectomy effects due to physiological similarities with humans.

Purpose of the Study:

  • To systematically investigate the long-term immunological and pathological consequences of vasectomy in primates.
  • To explore the potential link between vasectomy-induced immune responses and the development of arteriosclerosis.

Main Methods:

  • Longitudinal study of vasectomized and control rhesus and cynomolgus macaques (up to 14 years post-vasectomy).
  • Monitoring of antisperm antibody levels using sperm-agglutination, sperm-immobilization, and indirect immunofluorescence.
Keywords:
antibodiescardiovascularepididymisorchitisprimatesspermtestisvasectomy

More Related Videos

Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

10.5K
Optimizing the Modified No-Scalpel Vasectomy Technique
04:47

Optimizing the Modified No-Scalpel Vasectomy Technique

Published on: October 18, 2024

684

Related Experiment Videos

Last Updated: Dec 29, 2025

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model
09:33

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model

Published on: February 28, 2014

49.5K
Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

10.5K
Optimizing the Modified No-Scalpel Vasectomy Technique
04:47

Optimizing the Modified No-Scalpel Vasectomy Technique

Published on: October 18, 2024

684
  • Histopathological examination of testicular and epididymal tissues.
  • Immunofluorescence analysis of IgA, IgG, and C3 deposits in reproductive tissues.
  • Cardiovascular evaluation to assess arteriosclerosis severity.

    • Main Results:

    • Almost all vasectomized monkeys developed circulating antisperm antibodies; about 50% retained them.
    • Testicular changes (orchitis, aspermatogenesis) and epididymal pathology were significantly more prevalent in vasectomized monkeys.
    • Increased deposition of immune complexes (IgA, IgG, C3) was observed in the ductus efferens and caput epididymidis of vasectomized monkeys.
    • Vasectomized monkeys exhibited more frequent, extensive, and severe arteriosclerosis compared to controls.

    Conclusions:

    • Vasectomy in primates elicits significant, long-lasting immune responses and pathological changes in reproductive organs.
    • Evidence suggests vasectomy-induced immune complex formation may contribute to accelerated arteriosclerosis in monkeys.
    • Further epidemiological studies are needed to determine if similar cardiovascular effects occur in men after vasectomy.