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Evidence-Based Medical Management of Peripheral Artery Disease

Graham H Bevan1,2, Khendi T White Solaru1,3,2

  • 1From the Department of Medicine (G.H.B., K.T.W.S.), University Hospitals Cleveland Medical Center, OH.

Arteriosclerosis, Thrombosis, and Vascular Biology
|January 31, 2020
PubMed

Insights

Peripheral artery disease (PAD) management involves lifestyle changes and medical therapies to reduce cardiovascular risks. Effective treatment of PAD can prevent critical limb ischemia, amputation, and systemic atherosclerosis complications.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Surgery

Background:

  • Peripheral artery disease (PAD) is a prevalent atherosclerotic condition affecting lower extremities.
  • PAD significantly increases the risk of cardiovascular mortality, stroke, and myocardial infarction.
  • Compared to coronary artery disease, PAD is often undertreated.

Purpose of the Study:

  • To review the evidence supporting medical therapies for peripheral artery disease management.
  • To highlight the multifaceted approach to treating PAD.

Main Methods:

  • Literature review of medical therapies for PAD.
  • Analysis of evidence for cholesterol reduction, antiplatelet therapy, anticoagulation, vasodilators, blood pressure control, exercise, and smoking cessation.

Main Results:

  • Medical management of PAD includes a combination of pharmacologic and lifestyle interventions.
  • Adherence to treatment can mitigate limb-related complications (e.g., critical limb ischemia, amputation).
  • Effective PAD treatment also reduces systemic atherosclerotic events.

Conclusions:

  • Medical therapies are crucial for managing peripheral artery disease and improving patient outcomes.
  • A comprehensive approach combining lifestyle modifications and pharmacologic agents is essential.
  • Increased attention and treatment for PAD are warranted given its high mortality and morbidity.

Keywords:
atherosclerosisblood pressurecardiovascular diseasecholesterolperipheral artery diseasestrokevascular medicine

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