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Investigating associated factors with glomerular filtration rate: structural equation modeling
Parastoo Jamshidi1, Farid Najafi2, Shayan Mostafaei2,3
1School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMC Nephrology
|January 31, 2020
Summary
Aging, hypertension, and diabetes negatively impact kidney function, reducing glomerular filtration rate (GFR). Understanding these risk factors is crucial for improving kidney health and public awareness.
Area of Science:
- Nephrology
- Public Health
- Epidemiology
Background:
- Glomerular filtration rate (GFR) is a key indicator of kidney function.
- Various factors can influence GFR, necessitating detailed analysis.
- Understanding these factors is vital for kidney disease prevention and management.
Purpose of the Study:
- To assess the direct and indirect effects of GFR-related factors.
- To utilize structural equation modeling for comprehensive analysis.
- To differentiate effects between males and females.
Main Methods:
- Analysis of baseline data from the Ravansar Non-Communicable Disease cohort study.
- Application of a conceptual model to test direct and indirect effects.
- Structural equation modeling used for factor analysis in male and female cohorts.
Main Results:
- Hypertension and aging directly decrease GFR in both sexes. Atherogenic factors directly impact males and both directly/indirectly impact females.
- Blood urea nitrogen (BUN) and smoking are associated with lower GFR in both sexes.
- Diabetes decreases GFR directly and indirectly in females; obesity shows a mixed direct/indirect effect.
Conclusions:
- Aging, hypertension, diabetes, obesity, high lipid profile, and BUN negatively affect GFR through direct and indirect pathways.
- Findings align with existing research, offering detailed insights into low GFR risk factors.
- Increased public awareness of these risk factors can promote healthier behaviors and improve kidney health outcomes.
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