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Related Experiment Video

Updated: Dec 29, 2025

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Intraventricular Ectopic Cerebellum.

Alessandro De Benedictis1, Maria Camilla Rossi-Espagnet2, Francesca Diomedi-Camassei3

  • 1Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

World Neurosurgery
|January 31, 2020
PubMed
Summary

This study reports a rare case of ectopic cerebellar tissue found in a child's supratentorial ventricular system. This finding offers new insights into the developmental mechanisms of cerebellar ectopia.

Keywords:
Abnormal locationChildEctopic cerebellumLateral ventricleNeurosurgery

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pathology

Background:

  • Cerebellar ectopy is an exceptionally rare congenital anomaly.
  • Intraventricular cerebellar ectopia is exceedingly uncommon, with only one prior report in the fourth ventricle.

Observation:

  • A 9-year-old girl presented with chronic headaches, vomiting, and photophobia.
  • MRI revealed an intraventricular lesion in the left lateral ventricle with gray matter signal characteristics.
  • Histopathology confirmed ectopic cerebellar tissue with normal cerebellar architecture.

Findings:

  • This is the first documented case of cerebellar ectopia within the supratentorial ventricular system.
  • The ectopic tissue exhibited normal cerebellar cortical and white matter differentiation.
  • Imaging findings included an oval-shaped lesion with intermediate T1/T2 signals and reduced ADC values.

Implications:

  • Suggests a potential mechanism involving herniation of cerebellar germinal tissue into the ventricular system.
  • Highlights the importance of considering rare neurodevelopmental abnormalities in pediatric neurological cases.
  • Contributes to the understanding of congenital brain malformations and their embryological origins.