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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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YAP/TAZ functions and their regulation at a glance
Arianna Pocaterra1, Patrizia Romani1, Sirio Dupont2
1University of Padova, Department of Molecular Medicine, via Bassi 58/B, 35131 Padova, Italy.
Journal of Cell Science
|January 31, 2020
Summary
YAP and TAZ proteins regulate gene expression, promoting cell growth and tissue repair. Their dysregulation is linked to cancer, highlighting their central role in cellular signaling networks.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- YAP (Yes-associated protein) and TAZ (Transcriptional coactivator with PDZ-binding motif) are key transcriptional coactivators.
- They function downstream of the Hippo pathway, regulating gene expression by partnering with TEAD transcription factors.
- Nuclear localization of YAP/TAZ drives cell proliferation, survival, and tissue regeneration.
Purpose of the Study:
- To review the biological functions of YAP and TAZ proteins.
- To elucidate the regulatory mechanisms governing YAP/TAZ activity.
- To highlight the role of YAP/TAZ in cellular signaling and disease.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of YAP/TAZ interactions with TEAD factors.
- Examination of YAP/TAZ regulation by cellular and environmental cues.
Main Results:
- YAP/TAZ promote embryonic tissue growth, wound healing, and organ regeneration.
- Their activity is suppressed in many adult self-renewing tissues.
- Aberrant YAP/TAZ activity is implicated in cancer progression, drug resistance, and malignancy.
Conclusions:
- YAP/TAZ are central regulators of cell proliferation, survival, and tissue homeostasis.
- Their activity is intricately controlled by a network of intrinsic and extrinsic factors.
- Targeting YAP/TAZ pathways offers potential therapeutic strategies for cancer and regenerative medicine.
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