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Published on: September 9, 2015
Correlation between Broth Microdilution and Disk Diffusion Results when Testing Ceftazidime-Avibactam against a
Helio S Sader1, Paul R Rhomberg2, Sukantha Chandrasekaran3
1JMI Laboratories, North Liberty, Iowa, USA helio-sader@jmilabs.com.
Abstract:
We assessed the ceftazidime-avibactam disk diffusion breakpoints that provide the lowest discrepancy error rates by testing an Enterobacterales isolate collection with ceftazidime-avibactam MIC values near the breakpoints. Isolates (n = 112) were susceptibility tested by broth microdilution and disk diffusion methods in 3 laboratories. Current disk diffusion breakpoints (≥21/≤20 mm for susceptible/resistant) provided the lowest error rates, but confirmatory MIC testing is indicated for isolates with inhibition zones of 20 to 22 mm.
