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Updated: Dec 29, 2025
Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo
Min Li1, Chuanfeng Wang, Ting Wang
1Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China. xycui@chem.ecnu.edu.cn.
Abstract:
A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0-11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.
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