Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

14.4K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.4K
Tissue Transplantation01:24

Tissue Transplantation

820
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
820
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.1K
Overview
83.1K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.2K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.2K
Whole Body Regeneration01:33

Whole Body Regeneration

3.9K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.9K
Development of the Lymphatic System01:15

Development of the Lymphatic System

1.8K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AP1 Transcription Factor in the Regulation of the Urokinase Plasminogen Activation System.

Biomolecules·2026
Same author

The Cellular and Molecular Characteristics of Postnatal Human Thymus Stromal Stem Cells.

Biomedicines·2025
Same author

Urokinase Plasminogen Activation System Modulation in Transformed Cell Lines.

International journal of molecular sciences·2025
Same author

Analysis of Primary Chronic Lymphocytic Leukemia Cells' Signaling Pathways.

Biomedicines·2024
Same author

Design, Synthesis, and Biological Evaluation of Desmuramyl Dipeptides Modified by Adamantyl-1,2,3-triazole.

Molecules (Basel, Switzerland)·2021
Same author

MiR-7 in Cancer Development.

Biomedicines·2021

Related Experiment Video

Updated: Dec 29, 2025

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
03:31

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Published on: October 4, 2024

2.2K

Thymus Regeneration and Future Challenges.

Valentin P Shichkin1, Mariastefania Antica2

  • 1Bienta, Ltd, Chervonotkatska street 78, Kyiv, 02094, Ukraine. v.shichkin@bienta.net.

Stem Cell Reviews and Reports
|January 31, 2020
PubMed
Summary

Small chemical compounds offer a new approach to thymus regeneration by expanding thymic epithelial stem cells (TESC) in vitro. This method could lead to autologous thymus tissue regeneration for pediatric patients needing thymic repair.

Keywords:
Small chemical compoundsStem cellsThymectomised patientsThymic epithelial stem cellsThymusThymus regeneration

More Related Videos

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.4K
Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
07:20

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Published on: August 8, 2014

33.1K

Related Experiment Videos

Last Updated: Dec 29, 2025

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
03:31

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Published on: October 4, 2024

2.2K
Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.4K
Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
07:20

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Published on: August 8, 2014

33.1K

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Chemical Biology

Background:

  • Thymus regenerative therapy is limited by the low number and in vitro expansion capacity of thymic epithelial stem cells (TESC).
  • Current strategies rely on growth factors to differentiate pluripotent stem cells into TESC, which has limitations.

Purpose of the Study:

  • To explore target-specific small chemical compounds as an alternative strategy for TESC expansion and differentiation control.
  • To investigate the potential of these compounds for in vitro TESC culture and in vivo thymic regeneration.

Main Methods:

  • Identification and application of small chemical compounds targeting TESC.
  • Evaluation of compounds for their ability to induce clonal expansion and reversibly block differentiation of TESC.
  • Assessment of compounds for use in culture media and drug development for thymic regeneration.

Main Results:

  • Small chemical compounds can induce and support the clonal expansion of TESC.
  • These compounds can reversibly block TESC differentiation into mature cells.
  • The identified compounds show potential for both in vitro TESC expansion and in vivo therapeutic applications.

Conclusions:

  • Target-specific small chemical compounds present a promising alternative to growth factors for TESC expansion.
  • These compounds could facilitate autologous thymus tissue regeneration, particularly for pediatric patients post-cardiac surgery.
  • Further development of these compounds could significantly advance thymus regenerative therapies.