Related Experiment Video

Updated: Dec 29, 2025

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

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Trace Element Status in Children with Infantile Tremor Syndrome: An Inductively Coupled Plasma-Mass Spectrometry

Deepak Trinity Francis1, Savita Verma1, Prateek Bhatia2

  • 1Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Pediatrics
|January 31, 2020
PubMed

Insights

Infantile tremor syndrome (ITS) is strongly associated with vitamin B12 deficiency, not other trace elements. This finding supports ITS being a form of Neurocutaneous Infantile B-12 deficiency (NIB) syndrome.

Area of Science:

  • Pediatric Neurology
  • Nutritional Science

Background:

  • Infantile tremor syndrome (ITS) is a neurological disorder in infants.
  • The role of trace elements and vitamins in ITS pathogenesis requires further investigation.

Purpose of the Study:

  • To compare the trace element and vitamin B12 status in children with ITS versus healthy controls.
  • To investigate potential associations between nutrient deficiencies and ITS.

Main Methods:

  • Blood counts, serum vitamin B12, plasma homocysteine, plasma ferritin, magnesium, zinc, and selenium levels were analyzed.
  • Comparison between 26 children with ITS and 19 healthy controls.

Main Results:

  • Children with ITS showed significantly lower vitamin B12 levels (67% vs. 5%) and higher plasma homocysteine (96% vs. 26%) compared to controls.
  • No significant differences were observed in magnesium, zinc, or selenium levels between groups.
  • Hypoferritinemia was present in controls but not in ITS cases.

Conclusions:

  • ITS is strongly associated with vitamin B12 deficiency.
  • The findings support classifying ITS as Neurocutaneous Infantile B-12 deficiency (NIB) syndrome.
  • Trace elements like magnesium, zinc, and selenium do not appear to be primary factors in ITS.

Keywords:
CobalaminMalnutritionMicronutrientsMovement disorderNutritional deficiencyTropical disease

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