Abnormal Umblical Artery Doppler is Utilized for Fetuses with Intrauterine Growth Restriction Birth at 28^0/7-33^6/7...

Area of Science:

• Perinatology
• Neonatology
• Fetal Medicine

Background:

• Intrauterine growth restriction (IUGR) is a significant concern in preterm infants.
• Umbilical artery Doppler flow patterns, specifically absent or reversed end-diastolic blood flow (AREDF), can indicate placental insufficiency.
• The impact of AREDF on short-term perinatal outcomes in preterm infants with IUGR requires further elucidation.

Purpose of the Study:

• To compare short-term perinatal outcomes in preterm infants with IUGR.
• To evaluate differences between infants with AREDF and those with normal end-diastolic umbilical artery blood flow (NEDF).

Main Methods:

• Retrospective study of preterm infants (28 0/7–33 6/7 weeks) with IUGR.
• Comparison of outcomes between infants with AREDF (n=86) and NEDF (n=27).

Main Results:

• The AREDF group had lower mean gestational weeks and birth weights.
• AREDF infants showed a higher ratio of corticosteroid application.
• Neonatal intensive care unit (NICU) stay was significantly longer in the AREDF group (p < 0.001).
• Sepsis and feeding intolerance ratios were significantly higher in the AREDF group (p = 0.041 and p < 0.001, respectively).

Conclusions:

• Intrauterine growth restriction with umbilical Doppler abnormalities, specifically AREDF, is associated with adverse perinatal outcomes.
• These infants require longer NICU stays and are at higher risk for complications like sepsis and feeding intolerance.