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Related Experiment Video

Updated: Dec 29, 2025

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Published on: May 24, 2021

Large animal ischemic stroke models: replicating human stroke pathophysiology.

Erin E Kaiser¹, Franklin D West¹

¹Regenerative Bioscience Center; Neuroscience Program, Biomedical and Health Sciences Institute; Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, USA.

Neural Regeneration Research

|January 31, 2020

Summary

This summary is machine-generated.

Large animal models for ischemic stroke offer better prediction of human responses than rodent models. This review highlights their potential to improve stroke therapy translation and reduce clinical trial failures.

Keywords:

brain ischemia clinical translation gyrencephalic large animal model magnetic resonance imaging stroke

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Last Updated: Dec 29, 2025

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Area of Science:

Neuroscience
Translational Medicine
Animal Models

Background:

Ischemic stroke has high human morbidity and mortality.
Rodent models are widely used but have poor translation to clinical success.
There is a critical need for more clinically relevant animal models.

Purpose of the Study:

To review the characteristics of large animal ischemic stroke models.
To compare their pathophysiological responses and tissue changes to humans.
To assess their potential for improving stroke therapy translation.

Main Methods:

Review of existing literature on large animal ischemic stroke models.
Comparison of brain anatomy and physiology between large animals and humans.
Analysis of pathophysiological responses and tissue-level changes in models.
Evaluation of model limitations.

Main Results:

Large animal models (non-human primates, sheep, pigs, dogs) possess gyrencephalic brains similar to humans.
These models may offer more predictive insights into human stroke pathophysiology.
Potential for improved assessment of therapeutic interventions.

Conclusions:

Large animal models are crucial for advancing stroke therapy translational research.
Their anatomical and physiological similarities to humans enhance predictive value.
Further development and utilization of these models can bridge the gap between preclinical research and clinical outcomes.