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H3K36 Methylation in Neural Development and Associated Diseases
Mattia Zaghi1, Vania Broccoli1,2, Alessandro Sessa1
1Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
Frontiers in Genetics
|January 31, 2020
Summary
Post-translational methylation of H3 lysine 36 (H3K36) is a key epigenetic marker regulating gene transcription and DNA methylation. Dysregulation of H3K36 methylation is linked to various diseases, including cancer and neurological disorders.
Area of Science:
- Epigenetics
- Molecular Biology
- Genetics
Background:
- Post-translational methylation of H3 lysine 36 (H3K36) is a critical epigenetic modification.
- This mark influences fundamental cellular processes like gene transcription and DNA methylation.
- The precise regulation of H3K36 methylation is essential for maintaining cellular homeostasis.
Purpose of the Study:
- To review current knowledge on H3K36 methylation.
- To elucidate the molecular mechanisms governing H3K36 methylation abundance.
- To explore biological processes influenced by H3K36 methylation and associated diseases.
Main Methods:
- Literature review of epigenetic mechanisms.
- Analysis of molecular pathways regulating H3K36 methylation.
- Synthesis of data on H3K36 methylation and disease association.
Main Results:
- H3K36 methylation is regulated by specific enzyme classes.
- This epigenetic mark plays a role in gene transcription and DNA methylation.
- Impairment in H3K36 methylation homeostasis is linked to diverse diseases.
Conclusions:
- H3K36 methylation is a vital epigenetic signal with broad biological implications.
- Understanding the regulation and function of H3K36 methylation is crucial for disease research.
- Further investigation into H3K36 methylation mechanisms may offer therapeutic insights for associated pathologies.
Keywords:
DNA metyltransferases (Dnmts)H3K36SET – Su(var)3–9 and ‘Enhancer of zeste’histone methyl transferase (HMT)neurodevelopmentMore Related Videos
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