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Interferon-beta induced remission in a hairy cell leukemia patient resistant to interferon-alpha
R Michalevicz1, D Aderka, B Frisch
1Institute of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Rehovot, Israel.
Leukemia Research
|January 1, 1988
Abstract:
Two patients with advanced hairy cell leukemia and pancytopenia responded successfully to intramuscular injections of recombinant interferon-beta, with normalisation of blood counts. One of the patients had developed resistance to interferon-alpha. The in-vivo response was predicted by in-vitro studies showing a beneficial effect of IFN-beta on erythropoiesis in cell cultures derived from these patients.