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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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The Multifarious Link between Cytochrome P450s and Cancer

Abdullah M Alzahrani1, Peramaiyan Rajendran1

  • 1Department of Biological Sciences, College of Science, King Faisal University, Hofouf, 31982, Saudi Arabia.

Oxidative Medicine and Cellular Longevity
|January 31, 2020
PubMed

Insights

Cytochrome P450s (P450s) are crucial enzymes involved in drug metabolism. This review highlights their significant role in cancer development, prevention, and metastasis, offering insights into molecular mechanisms.

Area of Science:

  • Biochemistry
  • Oncology
  • Pharmacology

Background:

  • Cancer is a major global health concern.
  • Cytochrome P450s (P450s) are key enzymes in metabolizing endogenous and exogenous compounds, including drugs.
  • P450s are increasingly recognized for their dual role in cancer, acting as both contributors and therapeutic targets.

Purpose of the Study:

  • To elucidate the current understanding of cancer's molecular mechanisms involving P450 enzymes.
  • To consolidate research linking P450 enzyme activity to cancer formation, prevention, and metastasis.

Main Methods:

  • Comprehensive literature review of epidemiological, diagnostic, and clinical studies.
  • Analysis of molecular mechanisms underlying P450 involvement in carcinogenesis.
  • Synthesis of data on P450s in cancer progression and therapeutic strategies.

Main Results:

  • P450 enzymes significantly influence the initiation, progression, and spread of cancer.
  • Specific P450 isoforms are implicated in the metabolic activation or detoxification of carcinogens.
  • P450s present potential targets for novel cancer therapies and diagnostics.

Conclusions:

  • P450 enzymes are integral to cancer biology, affecting multiple stages of the disease.
  • Understanding P450-cancer interactions is vital for developing effective cancer prevention and treatment strategies.
  • Further research into P450 modulation holds promise for oncology.

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