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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Regulation of Angiogenesis and Blood Supply01:24

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
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Related Experiment Video

Updated: Dec 29, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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Noncoding RNAs in Vascular Aging.

Qidong Cao1, Jiuping Wu2, Xiaoli Wang3

  • 1Department of Cardiology, The Second Hospital Affiliated to Jilin University, Chang Chun, Jilin, China.

Oxidative Medicine and Cellular Longevity
|January 31, 2020
PubMed
Summary
This summary is machine-generated.

Vascular aging, linked to chronic diseases, involves cell senescence. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long ncRNAs (lncRNAs), regulate this process in endothelial cells (ECs) and vascular smooth muscle cells (VSMCs).

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Area of Science:

  • Vascular biology
  • Molecular biology
  • Aging research

Background:

  • Vascular aging is associated with chronic diseases like atherosclerosis and hypertension.
  • Noncoding RNAs (ncRNAs) are crucial regulators in physiological and pathological processes.
  • Senescence of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) contributes significantly to vascular aging.

Purpose of the Study:

  • To review the molecular mechanisms of EC and VSMC senescence.
  • To update on the regulatory roles of microRNAs (miRNAs) and long ncRNAs (lncRNAs) in vascular aging.

Main Methods:

  • Literature review of recent studies on ncRNAs and vascular aging.
  • Analysis of molecular mechanisms underlying cellular senescence in ECs and VSMCs.

Main Results:

  • ncRNAs, specifically miRNAs and lncRNAs, are key players in regulating vascular cell senescence.
  • The senescence of ECs and VSMCs is a critical driver of vascular aging.
  • Detailed molecular pathways of senescence in these cells are being elucidated.

Conclusions:

  • miRNAs and lncRNAs represent promising therapeutic targets for age-related vascular dysfunction.
  • Understanding ncRNA regulation of EC and VSMC senescence is vital for combating vascular aging.