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Related Experiment Video

Updated: Dec 29, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

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Published on: August 23, 2024

Membranous nephropathy associated with profound hypothyroidism.

Girish Singhania¹, Namrata Singhania²

¹Department of Hospital Medicine CHI St. Vincent Infirmary Little Rock AR USA.

Clinical Case Reports

|January 31, 2020

Summary

Hypothyroidism is a rare cause of secondary membranous nephropathy. Prompt thyroid function testing is recommended for patients with unexplained nephrotic proteinuria to identify this treatable condition.

Keywords:

acute renal failure angiotensin converting enzyme inhibitors hypothyroidism proteinuria

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Area of Science:

Nephrology
Endocrinology

Background:

Membranous nephropathy (MN) is a significant cause of nephrotic syndrome in adults.
MN can be idiopathic (primary) or secondary to various conditions.

Observation:

While malignancy and lupus are common causes of secondary MN, hypothyroidism is infrequently reported.
This highlights a potential underdiagnosis of thyroid dysfunction in MN patients.

Findings:

The study emphasizes the association between hypothyroidism and secondary membranous nephropathy.
Thyroid dysfunction should be considered in the differential diagnosis of secondary MN.

Implications:

Clinicians should consider thyroid screening in patients presenting with unexplained nephrotic proteinuria.
Early diagnosis and management of hypothyroidism may improve renal outcomes in affected individuals.