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Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
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Microfluidic formation of highly monodispersed multiple cored droplets using needle-based system in parallel mode.

Zheng Lian1,2, Yue Chan3, Yang Luo2

  • 1International Doctoral Innovation Centre, University of Nottingham Ningbo China, Ningbo, P. R. China.

Electrophoresis
|January 31, 2020
PubMed
Summary

This study presents a cost-effective method for scaling up droplet microfluidics using parallelized needle systems. This approach enhances production rates and maintains droplet monodispersity for diverse applications.

Keywords:
Double emulsionMicrofluidicsMultiple coresOff-the-shelf system

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Materials Science

Background:

  • Scaling up droplet microfluidics using traditional glass or polymer devices often compromises droplet size distribution or incurs high fabrication costs.
  • Existing methods for increasing production rates in microfluidic systems face challenges in maintaining droplet monodispersity and cost-effectiveness.

Purpose of the Study:

  • To introduce a novel, cost-effective method for scaling up droplet microfluidics through parallelization of needle-based systems.
  • To demonstrate enhanced production rates and maintain high droplet monodispersity in parallelized needle microfluidic systems.
  • To enable the formation of higher-order emulsions and microcapsules with complex structures for various applications.

Main Methods:

  • Parallelization of multiple needle-based microfluidic devices using commercially available two-way and 3D-printed four-way connectors.
  • Utilizing needles with specifications ranging from 34G to 20G for simultaneous generation of distinct microdroplet groups.
  • Tuning the capillary number of the middle phase to control core encapsulation in double emulsions.

Main Results:

  • Achieved production rates of over 660 droplets/min (fourfold increase) and over 1300 droplets/min (eightfold increase) compared to a single droplet maker (160 droplets/min).
  • Maintained high monodispersity (Coefficient of Variation < 3%) across simultaneously generated groups of polydimethylsiloxane (PDMS) microdroplets with distinct sizes.
  • Successfully encapsulated up to six cores in double emulsions by controlling the capillary number.

Conclusions:

  • Parallelization of needle-based microfluidic systems offers a scalable, cost-effective solution for high-throughput droplet generation.
  • This method supports the simultaneous production of multiple microdroplet populations with controlled sizes and complex structures.
  • The enhanced production yields and versatility position this technology for significant impact in biomedical (drug delivery, screening) and environmental (water treatment) applications.