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Updated: Dec 29, 2025

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
Published on: July 27, 2022
Essential Role of the ELABELA-APJ Signaling Pathway in Cardiovascular System Development and Diseases
Shuang Zhou, Jian Wang, Qingjie Wang
1Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Abstract:
ELABELA (ELA), previously classified as a "noncoding" RNA, is a new endogenous peptidic ligand of apelin receptor (APJ/APLNR), a class A (rhodopsin-like) G protein-coupled receptor. It has been identified to play a crucial role in diverse biological processes, especially in the normal and pathological cardiovascular system. In comparison with APJ's first ligand apelin, ELA may play a key role at different time points or heart regions. In this review, we summarized the roles of the ELA-APJ signaling pathway in cardiovascular system development and diseases.
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