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Hydrotropic Solubilization in Pharmaceutical Analysis: Origin, Evolution, Cumulative Trend and Precise Applications.

Mangesh R Patil1, Saurabh B Ganorkar1, Amod S Patil1

  • 1Central Instruments Facility (CIF), Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.

Critical Reviews in Analytical Chemistry
|February 1, 2020
PubMed
Summary

Hydrotropy enhances drug solubility for pharmaceutical analysis. This review traces its evolution, applications, and identifies atypical agents like Niacinamide, guiding future research in drug delivery.

Keywords:
Evolution classification trend and applicationshydrotropypharmaceutical analysis origin

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Area of Science:

  • Pharmaceutical Sciences
  • Analytical Chemistry

Background:

  • Hydrotropy, a solubilization technique, has been crucial in pharmaceutical analysis since 1982.
  • Its application in drug analysis evolved significantly over 66 years from its 1916 inception.

Purpose of the Study:

  • To provide a comprehensive overview of hydrotropy's origin, evolution, and applications in pharmaceutical analysis.
  • To critically evaluate literature on solubility enhancement of poorly soluble drugs using hydrotropic agents.

Main Methods:

  • A chronological and comparative assessment of published studies on hydrotropy.
  • Literature search yielding 77 references over 38 years.

Main Results:

  • Identified Ibuprofen sodium, Lignocaine, Niacinamide, and Metformin HCl as atypical hydrotropic agents.
  • Mono-hydrotropy approaches were found to be more prevalent than mixed approaches.
  • Possible solubilization mechanisms were presented.

Conclusions:

  • Hydrotropic agents play a crucial role in pharmaceutical analyses for improved drug delivery.
  • This review serves as a guideline for pharmaceutical analysts utilizing hydrotropy.
  • A classification system was proposed for future hydrotropy applications.