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MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression

Mu-N Liu, Shih-Jen Tsai, Heng-Liang Yeh

    Archives of Suicide Research : Official Journal of the International Academy for Suicide Research
    |February 1, 2020
    PubMed
    Abstract

    Insights

    Elevated levels of MCP-2/CCL8 chemokine were found in elderly men with major depressive disorder (MDD) and suicidal thoughts. This suggests MCP-2/CCL8 may play a role in depression-related suicidality.

    Area of Science:

    • Neuroscience
    • Immunology
    • Gerontology

    Background:

    • Major Depressive Disorder (MDD) is a prevalent condition in elderly males.
    • Suicidal Ideation (SI) is a serious concern in this demographic.
    • Chemokines, involved in immune responses, are increasingly studied for their role in psychiatric disorders.

    Purpose of the Study:

    • To compare serum chemokine levels in elderly males with MDD versus healthy controls.
    • To investigate differences in chemokine levels between MDD patients with and without current suicidal ideation (SI).

    Main Methods:

    • Serum samples were analyzed from 145 male elders (≥65 years).
    • Participants included MDD with SI (n=24), MDD without SI (n=23), and healthy controls (n=98).
    • Levels of 40 different chemokines were quantified.

    Main Results:

    • Patients with MDD and SI exhibited significantly higher serum levels of MCP-2/CCL8 compared to MDD patients without SI.
    • MCP-2/CCL8 levels were also elevated in the MDD with SI group relative to healthy controls (p < 0.001).

    Conclusions:

    • The chemokine MCP-2/CCL8 may be implicated in the pathophysiology of suicidality among elderly males experiencing depression.
    • These findings highlight a potential biomarker for assessing suicide risk in this population.
    Keywords:
    ChemokinesMCP-2/CCL8elderlymajor depressive disordersuicide

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