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Protective Role of Natural Products in Glioblastoma Multiforme: A Focus on Nitric Oxide Pathway

Amir R Afshari1, Hamid Mollazadeh1, Elmira Mohtashami2

  • 1Department of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Current Medicinal Chemistry
|February 1, 2020
PubMed

Insights

Glioblastoma Multiforme (GBM) is a fatal brain cancer. Targeting Nitric Oxide (NO) and its signaling pathways, potentially with natural products, offers new therapeutic strategies for GBM.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Glioblastoma Multiforme (GBM) remains a fatal brain cancer despite current treatments.
  • Nitric Oxide (NO) plays a significant role in GBM's complex biological processes.

Purpose of the Study:

  • To explore the role of Nitric Oxide (NO) as a therapeutic target in Glioblastoma Multiforme (GBM).
  • To review natural products that modulate the NO signaling pathway for potential GBM treatment.

Main Methods:

  • Literature review of studies on Nitric Oxide (NO) in GBM pathobiology.
  • Analysis of NO's involvement in key GBM processes like apoptosis, proliferation, and angiogenesis.
  • Identification of natural products targeting the NO pathway.

Main Results:

  • Nitric Oxide (NO) is implicated in critical GBM mechanisms including apoptosis, metastasis, proliferation, angiogenesis, and invasion.
  • The NO signaling pathway presents a viable target for novel GBM therapies.

Conclusions:

  • Targeting Nitric Oxide (NO) offers a promising therapeutic avenue for Glioblastoma Multiforme (GBM).
  • Natural products modulating NO signaling warrant further investigation for enhancing GBM treatment efficacy.
Keywords:
Glioblastoma multiformeangiogenesisapoptosismetastasisnatural productsnitric oxide

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