Related Experiment Video

Updated: Dec 29, 2025

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Published on: March 3, 2015

13.8K

Systematic comparison of the protein-protein interaction databases from a user's perspective

Akhilesh Kumar Bajpai1, Sravanthi Davuluri1, Kriti Tiwary2

  • 1Structural Biology Lab, Centre for Biomedical Research, School of Bio Sciences & Technology (SBST), Vellore Institute of Technology (VIT) University, Vellore 632014, Tamil Nadu, India; Shodhaka Life Sciences Pvt. Ltd., Electronic City, Phase I, Bengaluru (Bangalore) 560100, Karnataka, India.

Journal of Biomedical Informatics
|February 1, 2020
PubMed
Summary

Biologists often choose protein-protein interaction (PPI) databases subjectively. This study compares 16 human PPI databases, revealing STRING and UniHI cover 84% of verified interactions, while hPRINT, STRING, and IID capture 94% of total interactions.

Keywords:
Database and software selectionDatabase comparisonsMolecular networksProtein interaction databasesProtein interactionsSystems biology

More Related Videos

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

11.5K
Mapping Dysfunctional Protein-Protein Interactions in Disease09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

452

Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.4K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.3K
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.4K
Protein Networks02:26

Protein Networks

2.7K
Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.0K