Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preferences for tongue swab versus sputum collection for TB testing: a multi-country survey.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same author

Changes in fundus by optical coherence tomography in patients with chronic obstructive pulmonary disease: A systematic review.

The Medical journal of Malaysia·2025
Same author

Erratum: Centrality-Dependent Modification of Jet-Production Rates in Deuteron-Gold Collisions at sqrt[s_{NN}]=200  GeV [Phys. Rev. Lett. 116, 122301 (2016)].

Physical review letters·2025
Same author

Risk of cardiovascular diseases and gastrointestinal bleeding is comparable between celecoxib and non-selective non-steroidal anti-inflammatory drugs in patients with ankylosing spondylitis: a nationwide retrospective cohort study.

Scandinavian journal of rheumatology·2025
Same author

Efficacy, safety, and pharmacokinetics of eribulin as monotherapy or in combination with irinotecan for patients with pediatric rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, or Ewing sarcoma.

ESMO open·2025
Same author

First Measurement of Deeply Virtual Compton Scattering on the Neutron with Detection of the Active Neutron.

Physical review letters·2024

Related Experiment Video

Updated: Dec 29, 2025

Intra-Operative Neural Monitoring of Thyroid Surgery in a Porcine Model
08:16

Intra-Operative Neural Monitoring of Thyroid Surgery in a Porcine Model

Published on: February 11, 2019

21.9K

An Ultrasonically Powered Implantable Microprobe for Electrolytic Ablation.

A Kim1, S K Lee2, T Parupudi3,4

  • 1Department of Electrical and Computer Engineering, Temple University, Philadelphia, PA, 19122, USA. albertkim@temple.edu.

Scientific Reports
|February 1, 2020
PubMed
Summary
This summary is machine-generated.

A new wireless electrolytic ablation (EA) microprobe uses ultrasound for nonthermal tumor destruction by creating localized pH changes. This implantable device offers remote control and flexible dosing for cancer treatment.

More Related Videos

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

8.8K
The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
08:42

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

1.6K

Related Experiment Videos

Last Updated: Dec 29, 2025

Intra-Operative Neural Monitoring of Thyroid Surgery in a Porcine Model
08:16

Intra-Operative Neural Monitoring of Thyroid Surgery in a Porcine Model

Published on: February 11, 2019

21.9K
Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

8.8K
The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
08:42

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

1.6K

Area of Science:

  • Biomedical Engineering
  • Oncology
  • Minimally Invasive Surgery

Background:

  • Electrolytic ablation (EA) is a nonthermal tumor ablation method using direct current (DC) to induce locoregional pH changes.
  • Current EA techniques require invasive electrode placement and wired power, limiting clinical application and treatment flexibility.

Purpose of the Study:

  • To develop and evaluate an ultrasonically powered, implantable EA microprobe for wireless tumor ablation.
  • To enhance clinical relevance of EA through remote operation and fractionated dosing capabilities.

Main Methods:

  • A millimeter-sized microprobe with a piezoelectric ultrasonic receiver, rectifier circuit, and platinum electrodes was designed.
  • The microprobe was implanted minimally invasively into solid tumors.
  • Ultrasonic power (~200 mW/cm²) was used for wireless operation, generating DC (90 µA, 5 V) to create extreme pH changes.

Main Results:

  • The microprobe successfully generated localized acidic (pH < 2) and alkaline (pH > 12.9) regions.
  • pH changes extended to 0.8 cm³ within an hour in agarose gel, with an expansion rate of 0.5 mm³/min.
  • In vitro and ex vivo studies demonstrated microprobe-mediated EA capability in cancer cells and mouse liver.

Conclusions:

  • The ultrasonically powered EA microprobe offers a wireless, implantable solution for nonthermal tumor ablation.
  • This technology enhances EA's clinical applicability by enabling remote control and flexible treatment strategies.
  • The microprobe shows promise for effective cancer treatment with potential for repeated use in solid tumors.