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Published on: December 9, 2022
Great saphenous vein stump: a risk factor for superficial/deep venous thrombosis and an indication for prophylactic
Yasir Khan1, Muhammad Arslan Cheema1, Hafez Mohammad Ammar Abdullah2
1Department of Internal Medicine, Abington - Jefferson Health, Abington, USA.
Insights
The risk of blood clots in the great saphenous vein (GSV) stump after coronary artery bypass graft (CABG) surgery is low. Further studies are needed, but routine anticoagulation for GSV stump thrombosis is not currently recommended.
Area of Science:
- Vascular Surgery
- Cardiology
- Thrombosis Research
Background:
- Great saphenous vein (GSV) grafts are utilized in coronary artery bypass grafting (CABG).
- The GSV stump post-CABG may pose a risk for developing venous thrombosis.
- Lower extremity swelling is a potential indicator of GSV stump complications.
Purpose of the Study:
- To investigate the incidence of GSV stump thrombosis in patients experiencing lower extremity swelling post-CABG.
- To assess the risk factors associated with GSV stump thrombosis.
- To determine the necessity of prophylactic anticoagulation for GSV stump thrombosis.
Main Methods:
- A retrospective analysis of 100 patients undergoing CABG with GSV grafting was performed.
- Patients were monitored for seven days for saphenous vein thrombosis without prophylactic anticoagulation.
- Risk factors and confounding variables were recorded, and duplex ultrasound was used for diagnosis.
Main Results:
- Fourteen percent of patients developed lower extremity pain and swelling post-CABG.
- No cases of saphenous vein thrombosis in the GSV stump were detected via duplex ultrasound in symptomatic patients.
- The mean age of patients was 70 years, with 65% being male.
Conclusions:
- The postoperative risk of GSV stump thrombosis extending to deep veins appears to be low.
- Prophylactic anticoagulation for venous thromboembolism is not warranted based on these findings.
- Further prospective studies with larger sample sizes and longer durations are recommended to confirm these results.
Abstract:
Background: Great saphenous vein (GSV) grafts are used for coronary artery bypass surgeries, but the remaining stump of the GSV may be the nidus for superficial and deep vein thrombosis. This study aims to determine the risk of thrombosis in the GSV stump in patients who developed lower extremity swelling following coronary artery bypass graft (CABG). Methods: We conducted a single-center retrospective analysis at Abington Jefferson Hospital of 100 patients who underwent CABG with GSV. Patients were monitored via follow-up for seven days for the development of saphenous vein thrombosis without any prophylactic anticoagulation for venous thrombosis. Risk factors including age, diabetes, hypertension, smoking, familial thrombophilia's, family history of thrombosis, malignancy, and confounding factor-like early mobilization that may potentially alter the results were recorded. Results: The mean age of included patients was 70 years, and 65% of participants were men, 35% were women. Fourteen percent of the patients developed pain, swelling and edema in a leg where the graft was taken. We included patients aged >50 years with coronary artery disease who underwent CABG with SVG and developed lower extremity symptoms concerning for thrombosis. These patients underwent duplex ultrasound for possible GSV stump thrombosis. Any patients with coronary artery disease but no CABG or no lower extremity edema were excluded from the study. We found no saphenous vein thrombosis in the stump of the GSV in patients with clinical symptoms of thrombosis in their lower extremities based on duplex imaging. Conclusion: Based on our findings, the postoperative risk of developing thrombosis at the GSV stump and its extension to the deep veins is low and does not warrant prophylactic anticoagulation for venous thromboembolism. However, we recommend that further prospective studies with larger samples for an extended duration are warranted for better assessment of the risk of venous thrombosis in the GSV stump with minimal confounding factors.
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