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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
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Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
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Updated: Dec 29, 2025

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Pacinian hyperplasia presenting with Raynaud's phenomenon.

Brent B Pickrell1, Simon G Talbot1, Danielle C Costigan2

  • 1Division of Plastic Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

Case Reports in Plastic Surgery & Hand Surgery
|February 1, 2020
PubMed
Summary
This summary is machine-generated.

Pacinian corpuscle hyperplasia, a rare cause of digital pain, was identified in a patient with Raynaud's phenomenon. This case suggests a potential link between vascular conditions and Pacinian nerve endings.

Keywords:
CREST syndromePacinian corpuscleRaynaud’s phenomenondigital ischemiahand painhyperplasia

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Area of Science:

  • Neuroscience
  • Pathology
  • Rheumatology

Background:

  • Pacinian corpuscle pathology is an infrequent cause of digital pain.
  • Previous literature often links Pacinian corpuscle issues to hand trauma.
  • Raynaud's phenomenon is a vascular disorder affecting extremities.

Observation:

  • A case study involving a patient presenting with digital pain was analyzed.
  • The patient was diagnosed with Raynaud's phenomenon.
  • Histopathological examination revealed Pacinian hyperplasia.

Findings:

  • The study identified Pacinian hyperplasia in a patient with Raynaud's phenomenon, diverging from typical trauma-related cases.
  • This finding suggests a potential association between Raynaud's phenomenon and Pacinian corpuscle abnormalities.
  • A novel mechanism linking vascular changes in Raynaud's to Pacinian nerve hyperplasia is proposed.

Implications:

  • This research expands the understanding of differential diagnoses for digital pain.
  • It highlights the need to consider vascular conditions in Pacinian corpuscle pathology.
  • Further investigation into the pathophysiology of Pacinian hyperplasia in Raynaud's patients is warranted.