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Xenogeneic Lung Transplantation Models.

Lars Burdorf1, Agnes M Azimzadeh2, Richard N Pierson2

  • 1Center for Transplantation Sciences and Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Charlestown, MA, USA. lburdorf@mgh.harvard.edu.

Methods in Molecular Biology (Clifton, N.J.)
|February 1, 2020
PubMed
Summary
This summary is machine-generated.

Lung xenotransplantation research uses animal models to overcome barriers in organ transplantation. This chapter details ex vivo and in vivo lung xenograft models for future research.

Keywords:
Lung perfusionLung transplantationPulmonary xenograftXenogeneicXenotransplantation

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Area of Science:

  • Transplantation immunology
  • Xenotransplantation research
  • Surgical innovation

Background:

  • Lung xenografts are crucial for understanding xenotransplantation barriers.
  • Previous research provides a foundation for current xenotransplantation studies.
  • Challenges remain in achieving successful organ xenograft transplantation.

Purpose of the Study:

  • To review the history and current status of lung xenotransplantation.
  • To present two distinct experimental models: ex vivo porcine-to-human lung perfusion and in vivo xenogeneic lung transplantation.
  • To provide detailed technical information for adopting these lung xenograft models.

Main Methods:

  • Review of historical and current lung xenotransplantation literature.
  • Detailed description of ex vivo porcine-to-human lung perfusion model.
  • Step-by-step presentation of in vivo xenogeneic lung transplantation model.

Main Results:

  • Established protocols for ex vivo and in vivo lung xenograft models.
  • Identification of necessary materials and analytical techniques.
  • Framework for researchers to adopt and replicate lung xenograft experiments.

Conclusions:

  • Lung xenotransplantation models are vital for advancing transplantation science.
  • Detailed methodologies facilitate reproducibility and further research.
  • This work aims to reduce the learning curve for implementing lung xenograft studies.