Related Experiment Video
Updated: Dec 29, 2025
07:22
Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
Published on: August 19, 2021
3.3K
[Prospects of using bacteriophages in urological practice].
A A Shiryaev1, A O Vasilyev1, A V Zaitsev1
1Department of Urology, Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov, Moscow, Russia.
Urologiia (Moscow, Russia : 1999)
|February 1, 2020
Summary
Antimicrobial resistance necessitates new treatments for urinary tract infections. Bacteriophage therapy, using viruses that infect bacteria, offers a promising alternative to antibiotics for managing these challenging infections.
Area of Science:
- Urology
- Infectious Diseases
- Microbiology
Background:
- Antimicrobial resistance is a growing global health crisis, particularly impacting the treatment of urinary system infections.
- Increasing bacterial mutations lead to more aggressive strains, reducing antibiotic efficacy.
- Ineffective antibiotic therapy drives the need for alternative treatment strategies.
Purpose of the Study:
- To review the current literature on bacteriophage therapy for urinary tract infections.
- To explore the potential of phage therapy as an alternative to antibiotics.
- To highlight the mechanisms, benefits, and limitations of phage therapy in clinical practice.
Main Methods:
- Literature review of recent publications on bacteriophage therapy.
- Analysis of general aspects and mechanisms of action of bacteriophages.
- Evaluation of current applications, possibilities, and limitations in treating urinary system infections.
Main Results:
- Phage therapy is gaining significant traction as a viable treatment option.
- Bacteriophages demonstrate targeted action against specific bacterial pathogens.
- The review identifies key areas for the application and further research of phage therapy.
Conclusions:
- Phage therapy presents a promising alternative for combating antibiotic-resistant urinary tract infections.
- Understanding the mechanisms and limitations is crucial for successful clinical implementation.
- Further research is warranted to optimize phage therapy protocols for urinary system diseases.
Keywords:
antibacterial resistancebacterial strainsbacteriophagesphage therapyphagesurinary tract infectionMore Related Videos
Related Concept Videos
01:30Lytic Cycle of Bacteriophages
77.1K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
77.1K
01:29Microorganisms in Medicine and Therapeutics
868
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
868
01:26DNA Bacteriophages
649
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
649
00:43Lysogenic Cycle of Bacteriophages
67.2K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
67.2K
01:25Urinary Tract Infection II: Pathophysiology
491
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
491
01:28Biological Methods for Microbial Control
726
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
726