Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

1.5K
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
1.5K
Cholinergic Antagonists: Pharmacokinetics01:24

Cholinergic Antagonists: Pharmacokinetics

851
Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations,  while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
851
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship01:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

2.6K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generation and MHC class II loading of an endogenous influenza epitope revealed by a T cell receptor-like antibody.

bioRxiv : the preprint server for biology·2026
Same author

Long-term efficacy and safety of solifenacin, mirabegron, and their combination for overactive bladder: a systematic review.

Frontiers in pharmacology·2026
Same author

A novel borondifluoro indolenine-functionalized red-shift ratiometric fluorescent probe for detection of hypochlorous acid in drug-induced liver injury.

Talanta·2026
Same author

2s-DAS: Two-Stream Diffusion with Multi-Modal Fusion for Temporal Action Segmentation.

Journal of imaging·2026
Same author

Efficacy and safety of National Centralized Drug Procurement-procured versus non-National Centralized Drug Procurement oxaliplatin in unresectable or metastatic pancreatic cancer: a retrospective cohort study.

Translational cancer research·2026
Same author

Comparative effects of different exercise modalities on cognitive domains in older adults: a Bayesian network meta-analysis and meta-regression.

Frontiers in nutrition·2026

Related Experiment Video

Updated: Dec 29, 2025

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

470

Chalcone hybrids and their antimalarial activity.

Peng Cheng1, Linlin Yang2, Xiaodan Huang1

  • 1Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining, Shandong, China.

Archiv Der Pharmazie
|February 1, 2020
PubMed
Summary
This summary is machine-generated.

Drug-resistant malaria demands new treatments. Chalcone hybrids show promise as novel antimalarial agents, offering a new template for drug development against Plasmodium parasites.

Keywords:
antimalarialantiplasmodialchalconehybrid compoundsstructure-activity relationship

More Related Videos

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.9K
Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
08:31

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

Published on: October 11, 2019

10.8K

Related Experiment Videos

Last Updated: Dec 29, 2025

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

470
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.9K
Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
08:31

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

Published on: October 11, 2019

10.8K

Area of Science:

  • Medicinal Chemistry
  • Infectious Diseases
  • Drug Discovery

Background:

  • Malaria, caused by Plasmodium parasites, is a significant global health burden.
  • Emerging drug resistance in malaria necessitates the development of novel antimalarial therapies.
  • Chalcone derivatives possess diverse biological activities, making them attractive scaffolds for drug design.

Purpose of the Study:

  • To review recent advancements in chalcone hybrids as potential antimalarial agents.
  • To discuss the design principles and structure-activity relationships of these compounds.

Main Methods:

  • Literature review of recent studies on chalcone hybrids for antimalarial activity.
  • Analysis of structure-activity relationships (SAR) to identify key features for efficacy.

Main Results:

  • Chalcone hybrids exhibit promising in vitro and in vivo antimalarial activity.
  • Specific structural modifications of chalcones can enhance their potency against Plasmodium.

Conclusions:

  • Chalcone hybrids represent a viable template for developing new antimalarial drugs.
  • Further research into chalcone derivatives could lead to effective treatments for drug-resistant malaria.