Related Experiment Video
Updated: Dec 29, 2025
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Risk of Postoperative Up Staging or Upgrading among Men with Low Risk Familial Prostate Cancer
Fredrik Jansson1,2, Folke Folkvaljon3, Pär Stattin3
1Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweeden.
Purpose:
We investigated whether men with biopsy verified, low grade cancer and a family history of lethal or advanced prostate cancer are at particularly high risk for harboring undetected high grade disease.
Materials And Methods:
Upgrading and up staging of prostate cancer are common after prostatectomy. In a nationwide population based cohort we identified 6,854 men with low risk prostate cancer who underwent radical prostatectomy. Among these men 1,739 (25%) had a history of prostate cancer in a first-degree relative and 289 (4%) had a first-degree relative with lethal or advanced prostate cancer.
Results:
Compared to men with no familial occurrence of prostate cancer, the odds ratio for the risk of up staging among men with a familial occurrence of high risk or lethal prostate cancer was 1.06 (95% CI 0.76-1.47). The corresponding odds ratio for upgrading was 1.17 (0.91-1.50).
Conclusions:
We found no association between family history of prostate cancer and up staging or upgrading after radical prostatectomy.
