Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Tuberous sclerosis and trigonoseptal tumors].

P Bret1, J Remond, J Pialat

  • 1Service de Neurochirurgie C et U.F.R. Alexis Carrel, Hôpital Neurologique et Neurochirurgical P. Wertheimer, Lyon.

Neuro-Chirurgie
|January 1, 1988
PubMed
Summary

Tuberous sclerosis patients with midline ventricular tumors often present with increased intracranial pressure. Surgical intervention via a direct approach is generally preferred due to risks associated with conservative management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracystic chemotherapy with bleomycin in the treatment of craniopharyngiomas.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2002
Same author

Central nervous system cavernomas in the pediatric age group.

Neurosurgical review·2001
Same author

Hypothalamic hamartoma: the role of surgery in a series of eight patients.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2001
Same author

Zero rate of shunt infection in the first postoperative year in children--dream or reality?

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2000
Same author

Pediatric oligodendrogliomas.

Pediatric neurosurgery·1999
Same author

Syringomyelia associated with type I Chiari malformation. A 21-year retrospective study on 75 cases treated by foramen magnum decompression with a special emphasis on the value of tonsils resection.

Acta neurochirurgica·1998

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Tuberous sclerosis is a genetic disorder characterized by benign tumor formation in various organs.
  • Subependymal giant cell tumors (SEGTs) are a common intracranial manifestation of tuberous sclerosis.
  • These tumors, often located near the foramen of Monro, can cause significant neurological symptoms.

Purpose of the Study:

  • To report on a series of patients with tuberous sclerosis and associated midline ventricular tumors.
  • To evaluate the clinical presentation, imaging characteristics, and surgical outcomes of these tumors.
  • To discuss the optimal management strategy for SEGTs in the context of tuberous sclerosis.

Main Methods:

  • Retrospective case series of 9 patients with tuberous sclerosis and midline ventricular tumors.

Related Experiment Videos

  • Review of clinical data, neuroimaging (CT scans), and histopathological findings.
  • Surgical treatment approaches included direct transcortical transventricular approach and CSF shunting.

    • Main Results:

    • Midline ventricular tumors were the initial manifestation in most cases, presenting with increased intracranial pressure.
    • CT scans showed tumors enhancing after contrast injection, distinguishing them from other tuberous sclerosis-related lesions.
    • Surgical outcomes varied: 3 deaths, 3 excellent, 2 fair, and 1 poor result, evaluated based on preoperative neuropsychological status.

    Conclusions:

    • Subependymal giant cell tumors in tuberous sclerosis present a diagnostic and therapeutic challenge.
    • Direct surgical intervention is often favored over conservative management due to potential complications like CSF blockage or hemorrhage.
    • Early surgical consideration may improve outcomes in selected patients with tuberous sclerosis-associated ventricular tumors.