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Primary intraosseous malignant meningioma of the skull: case report
1Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Abstract:
Primary intraosseous meningioma of the skull is rare. This report describes a 61-year-old man who was treated by craniectomy 3 times for a repeatedly recurrent primary intraosseous malignant meningioma. Transmission electron microscopy revealed interdigitation of cytoplasmic processes, microfilaments, and distinct desmosomal structures. Immunocytochemical studies of cultured cells showed strong expression of vimentin and weakly positive staining for S-100 protein. Primary intraosseous malignant meningioma should be considered in the differential diagnosis of massive solitary osteolytic lesions of the skull.
Insights
Primary intraosseous meningioma, a rare skull tumor, was repeatedly treated in a 61-year-old man. This case highlights its aggressive nature and the need for consideration in skull osteolytic lesions.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Background:
- Primary intraosseous meningiomas are rare tumors arising within the skull bone, distinct from intracranial meningiomas.
- Recurrent and malignant forms present significant management challenges.
Observation:
- A case of a 61-year-old male with a repeatedly recurrent primary intraosseous malignant meningioma of the skull is presented.
- The patient underwent three craniectomies for tumor management.
- Histopathological analysis included transmission electron microscopy and immunocytochemistry.
Findings:
- Transmission electron microscopy revealed characteristic features such as interdigitated cytoplasmic processes, microfilaments, and desmosomes.
- Immunocytochemical studies demonstrated strong vimentin expression and weak S-100 protein positivity in cultured tumor cells.
Implications:
- Primary intraosseous malignant meningioma should be included in the differential diagnosis for massive solitary osteolytic skull lesions.
- This emphasizes the importance of thorough histopathological evaluation for accurate diagnosis and treatment planning.