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Updated: Dec 29, 2025

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Formal C-H Carboxylation of Unactivated Arenes
Ashot Gevorgyan1, Kathrin H Hopmann2, Annette Bayer1
1Department of Chemistry, UiT The Arctic University of Norway, 9037, Tromsø, Norway.
Abstract:
A formal C-H carboxylation of unactivated arenes using CO2 in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of 1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-symmetrically substituted benzenes, fluorinated benzenes and different heterocycles. The developed methodology was applied to the late-stage C-H carboxylation of commercial drugs and ligands.
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