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Updated: Dec 29, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Steven Bowers1, Eginia Franco1
1St. Luke's University Health Network, Bethlehem, PA, USA.
Chronic wounds, often mismanaged, require adherence to guidelines. Effective treatment involves the TIME principle (Tissue debridement, Infection control, Moisture balance, Edges of wound) tailored to specific lower extremity ulcer types.
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