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Related Experiment Video

Updated: Dec 29, 2025

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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Establishment of thromboelastography reference intervals by indirect method and relevant factor analyses.

Daye Cheng1, Xiaoying Li1, Shuo Zhao1

  • 1Transfusion Department, First Affiliated Hospital of China Medical University, Shenyang, China.

Journal of Clinical Laboratory Analysis
|February 1, 2020
PubMed
Summary
This summary is machine-generated.

Establishing reference intervals for thromboelastography (TEG) is crucial. An indirect method using stored data offers a feasible alternative, considering gender and age-specific effects for accurate interpretation of coagulation status.

Keywords:
indirect methodreference intervalthromboelastographytransfusion

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Area of Science:

  • Coagulation diagnostics
  • Laboratory medicine
  • Hemostasis research

Background:

  • Thromboelastography (TEG) is a valuable global coagulation test with decades of development.
  • Standardization and interpretation challenges, particularly regarding reference intervals (RIs), hinder widespread clinical application.
  • Traditional RI establishment is resource-intensive, prompting the need for alternative methods.

Purpose of the Study:

  • To establish RIs for Kaolin-activated TEG using an indirect method.
  • To investigate the influence of gender and age on TEG RIs.
  • To compare indirectly derived RIs with manufacturer-recommended values.

Main Methods:

  • Retrospective analysis of 930 TEG results.
  • Indirect method utilizing stored data and statistical calculations for RI determination.
  • Gender, age, and gender-dependent age subset analyses.

Main Results:

  • The indirect method successfully established RIs for R, K, αAngle, MA, and CI.
  • Females exhibited greater hypercoagulability compared to males.
  • Aging significantly impacted most TEG variables, with age 60 identified as a cutoff for males.

Conclusions:

  • The indirect method is a feasible approach for establishing TEG RIs.
  • Gender and age, particularly gender-dependent age effects, must be considered for accurate RI determination.
  • Indirectly derived RIs differ from manufacturer values but show high consistency for most parameters.