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Updated: Dec 29, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

Changrui Xing1, Youwen Zhuang2, Ting-Hai Xu3

  • 1Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, and NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA 15261, USA; Drug Discovery Institute and Departments of Computational Biology and of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Cell
|February 1, 2020
PubMed

Keywords:
3D Structure of Cannabinoid Receptor CB2Activation Mechanisms of CB2 and CB1Agonist-bound CB2- Gi Signaling ComplexCB2 AgonistCB2 Coupling Specificity for GiCB2 Drug DiscoveryCB2 Inverse AgonistCryo-EM structureGi Coupling VersatilityResidual Energy Contribution

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